Contrary to popular opinion, and the claims of several suppliers, Glucosamine Sulfate and Glucosamine Hydrochloride are chemically and structurally identical. For our full article on what Glucosamine is good for click here.
When glucosamine hydrochloride enters the digestive tract, it dissociates entirely to the base amino sugar and hydrochloric acid. When glucosamine sulfate enters the gastrointestinal tract, it separates into the base amino sugar, hydrochloric acid, and sodium sulfate. Consequently, each formulation contains only one organically active ingredient, and that is the glucosamine itself.
Some data suggest that the sulfate anion is a limiting factor in the circulation of glucosamine and can act as a boost to chondroitin if consumed in unison. However, these claims have not been proven fully, and further research is needed.